Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (10): 1418-1423. Previous Articles     Next Articles




  1. (贵州大学精细化工研究开发中心 教育部绿色农药和农业生物工程重点实验室 贵阳 550025)
  • 收稿日期:2006-01-17 修回日期:2006-03-20 发布日期:2006-09-19
  • 通讯作者: 宋宝安

Synthesis and Bioactivity of 2-Substitued Phenyl-5-(3,4,5-trimethoxy- phenyl)-1,3,4-oxadiazole Derivatives

CHEN Jiang,XU Rui-Qing,SONG Bao-An*,JIN Lin-Hong
HU De-Yu,YANG Song,ZHANG Guo-Ping   

  1. (Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development
    Center for Fine Chemicals, Guizhou University, Guiyang 550025)
  • Received:2006-01-17 Revised:2006-03-20 Published:2006-09-19
  • Contact: SONG Bao-An

Ten 2-substitued phenyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazoles were synthesized and characterized by elemental analysis, IR, 1H NMR and 13C NMR spectra. Bioassay of the title compounds indicated that some of them exhibited weak to moderate antitumor activity.

Key words: synthesis, antitumor activity, 1,3,4-oxadiazole derivative