Synthesis and Antitumor Activity of Oxazol-2-yl, Benzoxazol-2-yl and 1,3,4-Oxadiazol-2-yl Sulfur Ethers

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1432-1437. Previous Articles Next Articles

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噁唑、苯并噁唑及1,3,4-噁二唑硫醚的合成及抗肿瘤活性研究

张成仁，王柳，葛燕丽，巨修练*

(武汉工程大学化工与制药学院湖北省新型反应器与绿色化学工艺重点实验室武汉 430073)

收稿日期:2006-10-08 修回日期:2007-03-20 发布日期:2007-10-20
通讯作者: 巨修练

Synthesis and Antitumor Activity of Oxazol-2-yl, Benzoxazol-2-yl and 1,3,4-Oxadiazol-2-yl Sulfur Ethers

ZHANG Cheng-Ren,WANG Liu,GEYan-Li,JU Xiu-Lian*

(Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, School of Chemical Engi-neering and
Pharmacy, Wuhan Institute of Technology, Wuhan 430073)

Received:2006-10-08 Revised:2007-03-20 Published:2007-10-20
Contact: JU Xiu-Lian

Abstract

14 heterocylic sulfur ethers were designed and synthesized by the reaction of 2-thiol-oxazoles, 2-thiol-benzoxazoles and 2-thiol-1,3,4-oxadiazoles with alkyl halides, respectively, and those of 13 com-pounds have not been reported. All compounds were characterized by MS, ¹H NMR spectra and elemental analysis. The preliminary antitumor activities were investigated by MTT method and the results show that 10 compounds display a content of antitumor activity at the concentration of 10^－5 mol/L.

Key words: benzoxazole, 1,3,4-oxadiazole, antitumor activity, sulfur ether, oxazole

Cite this article

ZHANG Cheng-Ren,WANG Liu,GEYan-Li,JU Xiu-Lian*. Synthesis and Antitumor Activity of Oxazol-2-yl, Benzoxazol-2-yl and 1,3,4-Oxadiazol-2-yl Sulfur Ethers[J]. Chin. J. Org. Chem., 2007, 27(11): 1432-1437.

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噁唑、苯并噁唑及1,3,4-噁二唑硫醚的合成及抗肿瘤活性研究

Synthesis and Antitumor Activity of Oxazol-2-yl, Benzoxazol-2-yl and 1,3,4-Oxadiazol-2-yl Sulfur Ethers

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