Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (03): 498-502. Previous Articles     Next Articles

Reports

溴代二羟基硝基二苯醚类化合物的合成与抑菌活性研究

陈鸶a,辛莹b,詹妍c,侯若彤c,王玉良*,a
陈淑华a,杨志荣c   

  1. (a四川大学化学学院 成都 610064)
    (b成都医学院药学系 成都 610083)
    (c四川大学生命科学学院 成都 610064)
  • 收稿日期:2007-01-17 修回日期:2007-06-20 发布日期:2008-03-18
  • 通讯作者: 王玉良

ynthesis and Antimicrobial Activities of Brominated Dihy-droxyNitro Diphenyl Ethers

CHEN Sia,XIN Yingb,ZHAN Yanc,HOU Ruo-Tongc,WANG Yu-Liang*,a
CHEN Shu-Huaa, YANG Zhi-Rongc   

  1. (a College of Chemistry, Sichuan University, Chengdu 610064)
    (b Department of Pharmacy, Chengdu Medical College, Chengdu 610083)
    (c College of Life Science, Sichuan University, Chengdu 610064)
  • Received:2007-01-17 Revised:2007-06-20 Published:2008-03-18
  • Contact: WANG Yu-Liang

Dihydroxy nitro diphenyl ethers were prepared by acylation, nitration and hydrolysis from dihydroxy diphenyl ethers, then brominated by Br2 to give seven new brominated dihydroxy nitro diphenyl ethers. The structures of the new compounds have been confirmed by 1H NMR, IR, MS spectra and elemental analysis. These compounds showed good antimicrobial activities against the tested bacteria.

Key words: synthesis, brominated dihydroxy nitro diphenyl ether, antimicrobial activity