Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1676-1684. Previous Articles     Next Articles



赵圣印*; 邵志宇; 钦维民; 张灯青   

  1. (东华大学化学化工与生物工程学院 上海 201620)
  • 收稿日期:2007-12-24 修回日期:2008-02-19 发布日期:2008-10-20
  • 通讯作者: 赵圣印

Recent Progress in Indolylmaleimide Derivatives as Protein Kinase C Inhibitors

ZHAO, Sheng-Yin*; SHAO, Zhi-Yu ; QIN, Wei-Min ; ZHANG, Deng-Qing   

  1. (College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620)
  • Received:2007-12-24 Revised:2008-02-19 Published:2008-10-20
  • Contact: ZHAO, Sheng-Yin

Indolylmaleimides, derived from staurosporine, is a specific class of protein kinase C inhibitors. The structure modification, synthesis and biological activity of indolylmaleimide derivatives have been reviewed in this paper. The main parts were focused on the introduction of the synthetic routes. Both merits and limitations of the synthetic methods have been discussed.

Key words: protein kinase C inhibitor, indolylmaleimide, structure modification, biological activity, synthesis