Facile Synthesis, X-ray Structure and Anticancer Activity of N1-Alkylindirubin-3’-oxime

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (10): 1606-1610. Previous Articles Next Articles

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N1-烃基-3-肟基靛玉红的简便合成、晶体结构及抗肿瘤活性研究

王朝晖^a 王越^a冯明声^b 谭雪^b程景才^c 华维一^b 姚其正^*,b

(a中国药科大学基础部南京 210009) (b中国药科大学药学院南京 210009) (c无锡杰西医药科技有限公司无锡 214036)

收稿日期:2009-02-28 修回日期:2009-04-27 发布日期:2009-05-18

Facile Synthesis, X-ray Structure and Anticancer Activity of N1-Alkylindirubin-3’-oxime

Wang, Zhaohui^a Wang, Yue^a Feng, Mingsheng^b Tan, Xue^b Cheng, Jingcai^c Hua, Weiyi^bYao, Qizheng^*,b

(^a College of Basic Science, China Pharmaceutical University, Nanjing 210009) (^b School of Pharmacy, China Pharmaceutical University, Nanjing 210009) (^c Wuxi JC Pharmaceutical Technology Inc., Wuxi 214036)

Received:2009-02-28 Revised:2009-04-27 Published:2009-05-18

Abstract

A novel synthetic method of N1-alkylindirubin-3-oxime (3a～3c) was explored using indirubin as the starting material, including N-alkylation and oximation. Crystal X-ray diffraction studies of N1-ethylindirubin-3-oxime (3b) gave good support for the (3Z,3E) structure. The anticancer activity of compounds 3a～3c was evaluated and compound 3b showed potent anticancer effect and low toxicity com-pared to other chemotherapy drugs .

Key words: N1-alkylindirubin-3-oxime, synthesis, crystal structure, anticancer activity

Cite this article

WANG Chao-Hui, WANG Huo, FENG Meng-Qing, TAN Xue, Cheng-Jing-Cai, HUA Wei-Yi, TAO Ji-Zheng. Facile Synthesis, X-ray Structure and Anticancer Activity of N1-Alkylindirubin-3’-oxime[J]. Chin. J. Org. Chem., 2009, 29(10): 1606-1610.

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N1-烃基-3-肟基靛玉红的简便合成、晶体结构及抗肿瘤活性研究

Facile Synthesis, X-ray Structure and Anticancer Activity of N1-Alkylindirubin-3’-oxime

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