Study on the Reaction of Substituted Salicylaldehydes with Cyanoacetate in Water
WANG Xiang-Shan*,a,b,c,ZENG Zhao-Sena,LI Yu-Linga,c,SHI Da-Qinga,c
TU Shu-Jianga,c,WEI Xian-Yongb,ZONG Zhi-Minb
(a Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
(b School of Chemical Engineering, China University of Mining and Technol-ogy, Xuzhou 221008)
(c Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116)
Two series of chromene derivatives were synthesized from the substituted salicylaldehyde with cyanoacetate in water at two reaction temperatures catalyzed by triethylbenzyl ammonium chloride (TEBAC). Such method has the advantages of easier work-up, milder reaction conditions, better yields than other synthetic methods.