One-Step Syntheses of Pyrano[2,3-d]pyrimidine Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1420-1423. Previous Articles Next Articles

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三乙基苄基氯化铵催化下水介质中吡喃并[2,3-d]嘧啶衍生物的一步合成

梁静*^,a，张梅梅^b，魏贤勇^a，宗志敏^a，王香善^b

(^a中国矿业大学化工学院徐州 221116)
(^b徐州师范大学化学系徐州 221116)

收稿日期:2007-03-07 修回日期:2007-05-24 发布日期:2007-10-20
通讯作者: 梁静

One-Step Syntheses of Pyrano[2,3-d]pyrimidine Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride

LIANG Jing*^,a,ZHANG Mei-Mei^b,WEI Xian-Yong^a
ZONG Zhi-Min^a,WANG Xiang-Shan^b

(^aSchool of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116)
(^bDepartment of Chemistry, Xuzhou Normal University, Xuzhou 221116)

Received:2007-03-07 Revised:2007-05-24 Published:2007-10-20
Contact: LIANG Jing

Abstract

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized from arylidene malononitrile and 1,3-dimethyl barbital at 100 ℃ catalyzed by triethylbenzylammonium chloride (TEBAC) in water. This method has many advantages, such as mild reaction conditions, high yields (78%～90%) and environmental friendliness. The structures of the products were characterized by IR, ¹H NMR spectra and elemental analyses, and further confirmed by X-ray diffraction analysis.

Key words: triethylbenzylammonium chloride, water, synthesis, pyrano[2,3-d]pyrimidine

Cite this article

LIANG Jing*^,a,ZHANG Mei-Mei^b,WEI Xian-Yong^a
ZONG Zhi-Min^a,WANG Xiang-Shan^b. One-Step Syntheses of Pyrano[2,3-d]pyrimidine Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride[J]. Chin. J. Org. Chem., 2007, 27(11): 1420-1423.

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三乙基苄基氯化铵催化下水介质中吡喃并[2,3-d]嘧啶衍生物的一步合成

One-Step Syntheses of Pyrano[2,3-d]pyrimidine Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride

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