Synthesis and Bioactivity of 6-Fluoro-4-(N-aryl)aminoquinazoline Compounds under Microwave Irradiation

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (9): 1275-1278. Previous Articles Next Articles

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6-氟-4-(N-芳基)胺基喹唑啉类化合物的微波合成及生物活性研究

张培权，宋宝安*，杨松，金林红
胡德禹，刘刚，薛伟

(^a贵州大学精细化工研究开发中心教育部绿色农药和农业生物工程重点实验室贵阳 550025)

收稿日期:2005-09-13 修回日期:2006-01-15 发布日期:2006-09-11
通讯作者: 宋宝安

Synthesis and Bioactivity of 6-Fluoro-4-(N-aryl)aminoquinazoline Compounds under Microwave Irradiation

ZHANG Pei-Quan,SONG Bao-An*,YANG Song,JIN Lin-Hong
HU De-Yu,LIU Gang,XUE Wei

(^aKey Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development Centre for Fine Chemicals, Guizhou University, Guiyang 550025)

Received:2005-09-13 Revised:2006-01-15 Published:2006-09-11
Contact: SONG Bao-An

Abstract

Six new 6-fluoro-4-(N-aryl)aminoquinazoline compounds were synthesized, firstly by the cycli-zation reaction of 2-amino-5-fluorobenzoic acid with formamide and then chlorination to attain 4-chloro-6-fluoroquinazoline, finally the amination with arylamines under microwave irradiation. The structures of the six new compounds were characterized by elemental analyses, IR and ¹H NMR spectra. Bioactivity of the new compounds was tested. The results showed that the six new compounds had weak anticancer activity to PC3, BGC823, BCap-37 and ERK phosphorylation in NIH3T3 cell induced by PDGF.

Key words: synthesis, microwave irradiation, fluorine, bioactivity, qunazoline

Cite this article

ZHANG Pei-Quan,SONG Bao-An*,YANG Song,JIN Lin-Hong
HU De-Yu,LIU Gang,XUE Wei. Synthesis and Bioactivity of 6-Fluoro-4-(N-aryl)aminoquinazoline Compounds under Microwave Irradiation[J]. Chin. J. Org. Chem., 2006, 26(9): 1275-1278.

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6-氟-4-(N-芳基)胺基喹唑啉类化合物的微波合成及生物活性研究

Synthesis and Bioactivity of 6-Fluoro-4-(N-aryl)aminoquinazoline Compounds under Microwave Irradiation

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