Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (10): 1951-1957.DOI: 10.6023/cjoc1203162 Previous Articles     Next Articles



熊启中, 刘军虎, 林选福, 鲍小平   

  1. 贵州大学精细化工研究开发中心 教育部绿色农药与农业生物工程重点实验室 贵阳 550025
  • 收稿日期:2012-03-16 修回日期:2012-05-15 发布日期:2012-06-04
  • 通讯作者: 鲍小平
  • 基金资助:

    贵州省优秀科技教育人才省长专项资金(No. 200817)资助项目.

Synthesis and Fungicidal Activities of 2-Benzylsulfonyl-5-methyl- 1,2,4-triazolo[1,5-a]pyrimidine-7-oxoacetohydrazone Derivatives

Xiong Qizhong, Liu Junhu, Lin Xuanfu, Bao Xiaoping   

  1. Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025
  • Received:2012-03-16 Revised:2012-05-15 Published:2012-06-04
  • Supported by:

    Project supported by the Governor’s Foundation for Excellent Talents of Science, Technology & Education of Guizhou Province (No. 200817).

Twenty four novel 2-benzylsulfonyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine-7-oxoacetohydrazone derivatives 5a5x were synthesized by utilization of 2-benzylthio-5-methyl-7-hydroxyl-1,2,4-triazolo[1,5-a] pyrimidine as starting material. All the target compounds were characterized by 1H NMR, IR, MS and elemental analysis. The preliminary bioassay indicated that the inhibition rates of 4-methoxybenzaldehyde N-[2-benzylsulfonyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine]- 7-oxoacetohydrazone (5k), 2-choro-5-nitrobenzaldehyde N-[2-benzylsulfonyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine]-7- oxoacetohydrazone (5p) and cinnamaldehyde N-[2-benzylsulfonyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine]-7-oxoaceto- hydrazone (5s) against Botrytis cinerea reached above 70% at the concentration of 50 μg/mL.

Key words: 1,2,4-triazolo[1,5-a]pyrimidine, sulfone, acetohydrazone, synthesis, fungicidal activity