Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (07): 1536-1539.DOI: 10.6023/cjoc201301039 Previous Articles     Next Articles



郑娟a, 陈雨b, 吴孔丽a, 冉春玲a, 徐琰a, 宋毛平a   

  1. a 郑州大学化学与分子工程学院 郑州 450001;
    b 郑州大学基础医学院 郑州 450001
  • 收稿日期:2013-01-16 修回日期:2013-03-07 发布日期:2013-03-15
  • 通讯作者: 徐琰
  • 基金资助:

    国家自然科学基金(No. 21171149)资助项目.

Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles

Zheng Juana, Chen Yub, Wu Konglia, Ran Chunlinga, Xu Yana, Song Maopinga   

  1. a College of Chemistry and Molecular Engineering, Zhengzhou 450001;
    b College of Basic Medicine, Zhengzhou University, Zhengzhou 450001
  • Received:2013-01-16 Revised:2013-03-07 Published:2013-03-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21171149).

Four new 2,5-disubstituted 1,3,4-oxadiazole derivative N-(5-aromatic-1,3,4-oxadiazol-2-yl)picolinamides 2a2d were obtained by condensation, oxidization and acylation reactions, with isonicotinic acid and single substituted aromatic aldehydes as raw materials. These compounds were characterized by IR, 1H NMR and elemental analysis. Fluorescence test results indicated that Cu2+ could make this series compounds fluorescence quenching, and Zn2+could only enhance the fluorescence intensity of N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]isonicotinamide (2b). Furthermore, those compounds all showed good fungicidal activity against the tested bacteria, and among them, N-(5-p-tolyl-1,3,4-oxadiazol-2-yl)isonicotinamide (2d) against Gibberella zeae was reached 100%.

Key words: 1,3,4-oxadiazole, fluorescence, biological activity