Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (09): 1919-1931.DOI: 10.6023/cjoc201301051 Previous Articles     Next Articles



王春超, 谢绍雷, 解正峰   

  1. 新疆大学化学化工学院 石油天然气精细化工教育部&新疆维吾尔自治区重点实验室 乌鲁木齐 830046
  • 收稿日期:2013-01-21 修回日期:2013-03-18 发布日期:2013-04-07
  • 通讯作者: 解正峰
  • 基金资助:

    国家自然科学基金(Nos. 21262034, 20962018, 20862015, 20562011)资助项目

Research Progress in Friedel-Crafts Reaction of Indoles and Nitroalkenes

Wang Chunchao, Xie Shaolei, Xie Zhengfeng   

  1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2013-01-21 Revised:2013-03-18 Published:2013-04-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21262034, 20962018, 20862015, 20562011)

Indoles, as the core structure, exist widely in many alkaloid natural products and pharmaceuticals. The derivatives of indole play an important role in organism physiological activities. The Friedel-Crafts reaction of indoles and nitroalkenes is an important method to generate indole derivatives. According to the kinds of the catalyst in the reaction, the Friedel-Crafts reactions of indoles and nitroalkenes were summarized in this paper as follows: (1) catalyst-free, (2) ionic liquid catalyst, (3) metal salt catalyst, (4) coordination compound catalyst, (5) Brønsted acid catalyst, (6) small molecular organic catalyst, (7) other catalysts.

Key words: Friedel-Crafts reaction, indole, nitroolefin, catalyst