Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1341-1350.DOI: 10.6023/cjoc201601001 Previous Articles     Next Articles



李新民, 刘春, 刘超, 金子林   

  1. 大连理工大学精细化工国家重点实验室大连 116012
  • 收稿日期:2016-01-02 修回日期:2016-01-20 发布日期:2016-02-24
  • 通讯作者: 刘春
  • 基金资助:


Palladium-Catalyzed Ligand-Free Suzuki Reaction of Potassium Aryltrifluoroborates in Aqueous Ethanol

Li Xinmin, Liu Chun, Liu Chao, Jin Zilin   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012
  • Received:2016-01-02 Revised:2016-01-20 Published:2016-02-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21276043, 21421005) and the Research Foundation of Dalian University of Technology for Retired Professors (No. DUTTX2015102).

A simple and ligand-free protocol has been developed for the Pd(OAc)2-catalyzed Suzuki reaction of potassium aryltrifluoroborates in aqueous ethanol under air. In the presence of Pd(OAc)2 and 1 equiv. of K2CO3, aryl or heteroaryl halides coupled with various potassium aryltrifluoroborates smoothly to afford the products in high yields with the highest turnover frequency (TOF) up to 4656 h-1, and a series of triphenylamine derivatives were prepared efficiently in this system. In addition, the active catalyst was proved to be the in situ-generated palladium nanoparticles according to TEM analysis and mercury-poisoning test.

Key words: palladium, ligand-free, Suzuki reaction, potassium aryltrifluoroborates, aqueous ethanol