Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (10): 3373-3381.DOI: 10.6023/cjoc202209002 Previous Articles     Next Articles

Special Issue: 不对称催化专辑



贾仕虎a, 陈思元a, 刘泽水a,b, 程鸿刚a,*(), 周强辉a,c,*()   

  1. a 武汉大学化学与分子科学学院 武汉 430072
    b 郑州大学化学学院 绿色催化中心 郑州 450001
    c 武汉大学高等研究院 武汉 430072
  • 收稿日期:2022-09-01 修回日期:2022-10-11 发布日期:2022-11-02
  • 通讯作者: 程鸿刚, 周强辉
  • 基金资助:
    国家自然科学基金(21871213); 国家自然科学基金(22071189); 中央大学基础研究基金(2042021kf0214)

Pd/Novel Axially Chiral Phosphine-Alkene Ligands Catalyzed Asymmetric Allylic Alkylation of Indoles

Shihu Jiaa, Siyuan Chena, Zeshui Liua,b, Honggang Chenga(), Qianghui Zhoua,c()   

  1. a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
    b Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001
    c The Institute for Advanced Studies, Wuhan University, Wuhan 430072
  • Received:2022-09-01 Revised:2022-10-11 Published:2022-11-02
  • Contact: Honggang Cheng, Qianghui Zhou
  • Supported by:
    National Natural Science Foundation of China(21871213); National Natural Science Foundation of China(22071189); Fundamental Research Funds for Central Universities(2042021kf0214)

A new type of axially chiral phosphine-alkene ligands have been developed via a two-step modular synthesis for Pd-catalyzed asymmetric allylic alkylation of indoles. Under optimized reaction conditions, a series of chiral allylindole products were obtained in generally high yields (up to 95%) and excellent enantioselectivities (up to 96% ee).

Key words: palladium catalysis, phosphine-alkene ligand, indole, allylic alkylation, asymmetric catalysis