Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 375-384.DOI: 10.6023/cjoc201608010 Previous Articles     Next Articles



王家尧, 姜锐, 梁晓梅, 金淑惠, 王道全, 张建军   

  1. 中国农业大学理学院 北京 100193
  • 收稿日期:2016-08-17 修回日期:2016-10-08 发布日期:2016-11-03
  • 通讯作者: 金淑惠, 张建军;
  • 基金资助:


Efficient Synthesis of Epilactose

Wang Jiayao, Jiang Rui, Liang Xiaomei, Jin Shuhui, Wang Daoquan, Zhang Jianjun   

  1. China Agricultural University, Beijing 100193
  • Received:2016-08-17 Revised:2016-10-08 Published:2016-11-03
  • Supported by:

    Project supported by the National Science & Technology Pillar Program of China (No. 2015BAK45B01).

Epilactose (4-O-β-D-galactopyranosyl-D-mannose) is a reducing disaccharide with satisfactory prebiotic properties. A superior synthetic methods were confirmed by screening different coupled donors and acceptors which were synthesized from D-mannose and D-galactose, respectively. This route gets 50% overall yields and all the intermediates are easily to be purified, making the route suitable for large scale preparation of the target compound. All the compounds were characterized by NMR and HRMS spectra.

Key words: epilactose, D-mannose, D-galactose, synthesis