Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (3): 746-752.DOI: 10.6023/cjoc201607010 Previous Articles     Next Articles



汤玲娟a,b, 陆新谋b, 纪顺俊b   

  1. a 南通大学分析测试中心 南通 226019;
    b 江苏省有机合成重点实验室 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2016-07-05 修回日期:2016-10-19 发布日期:2016-12-12
  • 通讯作者: 纪顺俊,
  • 基金资助:


Base Promoted Annulation of Carbodiimides to Access of Quinazoline and Their Derivatives

Tang Lingjuana,b, Lu Xinmoub, Ji Shunjunb   

  1. a Analysis and Testing Center, Nantong University, Suzhou 226019;
    b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2016-07-05 Revised:2016-10-19 Published:2016-12-12
  • Contact: 10.6023/cjoc201607010
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372174, 21542015), the Priority Academic Program Development of Jiangsu Higher Education Institutions.

An efficient methodology to access of quinazoline derivatives by the reaction of carbodiimides and alcohol under basic conditions has been developed. This paper provides an attractive strategy for construction of the quinazoline compounds and other heterocyclic compounds in a high reaction yield by using simple starting materials in mild reaction conditions and short reaction time.

Key words: carbodiimides, α,β-unsaturated ketone, quinazoline and their derivatives, metal-free