Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2221-2236.DOI: 10.6023/cjoc201703041 Previous Articles     Next Articles



蒋凯a, 曹梁a, 郝志峰b, 陈美燕a, 程洁銮a, 李晓a, 肖萍a, 陈亮a, 汪朝阳a   

  1. a 华南师范大学化学与环境学院 教育部环境理论化学重点实验室 广州 510006;
    b 广东工业大学轻工化工学院 广州 510006
  • 收稿日期:2017-03-24 修回日期:2017-05-14 发布日期:2017-05-25
  • 通讯作者: 汪朝阳, 郝志峰;
  • 基金资助:


Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes

Jiang Kaia, Cao Lianga, Hao Zhifengb, Chen Meiyana, Cheng Jieluana, Li Xiaoa, Xiao Pinga, Chen Lianga, Wang Zhaoyanga   

  1. a School of Chemistry and Environment, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, South China Normal University, Guangzhou 510006;
    b School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006
  • Received:2017-03-24 Revised:2017-05-14 Published:2017-05-25
  • Contact: 10.6023/cjoc201703041;
  • Supported by:

    Project supported by the Guangzhou Science and Technology Project Scientific Special (No. 201607010251), the Applied Science and Technology Research and Development Special Foundation of Guangdong Province (No. 2016B090930004), the Undergraduates Innovation Project of South China Normal University (No. 20161415), the Natural Science Foundation of Guangdong Province (No. 2014A030313429) and the Guangdong Provincial Science and Technology Project (No. 2017A010103016).

Benzothiazole group is of characteristic fluorescence, and each also contains two heteroatoms (N and S). Hence, benzothiazole group is always viewed as fluorophore and recognition moiety in structure of fluorescent probes, playing an essential role on provision of fluorescence signal and binding sites. Recently, utilizing these properties of benzothiazole moiety to design and synthesize better fluorescent probes has gradually become one of focuses in fluorescent detection research. Classifying benzothiazole-based fluorescent probes into four main categories according to different analytes, such as metal cations, anions, sulfur-containing compounds and other species, the design, synthesis, detecting mechanism and relevant application of these probes are reviewed. And their development tendency in the future is prospected.

Key words: benzothiazole, fluorescent probe, design and synthesis, detecting application, progress