Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 363-376.DOI: 10.6023/cjoc201806021 Previous Articles     Next Articles



苏琳, 侯卫   

  1. 浙江工业大学药学院 杭州 310014
  • 收稿日期:2018-06-15 修回日期:2018-08-02 发布日期:2018-09-10
  • 通讯作者: 侯卫
  • 基金资助:


Progress in the Synthesis of Cinnoline Derivatives

Su Lin, Hou Wei   

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2018-06-15 Revised:2018-08-02 Published:2018-09-10
  • Contact: 10.6023/cjoc201806021
  • Supported by:

    Project supported by the Scientific Start-Up Funding from Zhejiang University of Technology (No. 2017116002229) and the China Postdoctoral Science Foundation (No. 2017M612024).

Cinnolines are "privileged scaffold" in new material and drug research, and development for their extensive biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory, and sedative activities and good electron-accepting ability. As a result, the development of new synthetic routes to this important structure has been actively investigated in recent years. Especially, the C-H functionalization strategy has promoted the development of new methods greatly. The recent advances of the synthetic methods to cinnolines based on different synthetic strategies and raw materials are reviewed.

Key words: cinnolines, C-H functionalization, coupling, tandem reaction