Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 54-69.DOI: 10.6023/cjoc202306011 Previous Articles     Next Articles



童红恩, 郭宏宇*(), 周荣*()   

  1. 太原理工大学化学学院 太原 030024
  • 收稿日期:2023-06-13 修回日期:2023-08-03 发布日期:2023-09-15
  • 基金资助:

Progress on Visible-Light Promoted Addition Reactions of Inert C—H Bonds to Carbonyls

Hong'en Tong, Hongyu Guo(), Rong Zhou()   

  1. College of Chemistry, Taiyuan University of Technology, Taiyuan 030024
  • Received:2023-06-13 Revised:2023-08-03 Published:2023-09-15
  • Contact: *E-mail:; E-mail:
  • Supported by:
    Natural Science Foundation of Shanxi Province(202203021222117)

Secondary and tertiary alcohols are important structural motifs that often exist in a large number of bioactive natural products and pharmaceuticals. Moreover, they can also be used as upstream raw material for preparation of various highly valuable chemicals. Among the existing synthetic methodologies for preparation of these compounds, the nucleophilic addition of nucleophiles to aldehydes and ketones represents one of the most operative ways. However, pre-functionalized substrates are always needed for this protocol, resulting in low efficiency and poor atom economy. The growing area of photocatalysis has provided a mild and effective approach for inert C—H bond activation. As a result, the photocatalytic straight addition of inert C—H bond to carbonyls has been developed, which affords the synthesis of secondary and tertiary alcohols in a new manner. The visible-light induced addition reaction of inert C—H bond to carbonyls was classified by three different mechanisms: reductive radical-polar crossover (RRPCO), radical-radical cross coupling as well as radical addition, and reviewed, respectively. Finally, the limitations and future developments of this research field are discussed.

Key words: secondary alcohol, tertiary alcohol, visible-light catalysis, reductive radical-polar crossover, radical-radical cross coupling, radical addition