Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3132-3144.DOI: 10.6023/cjoc201903008 Previous Articles     Next Articles

碱性磷酸酶荧光探针的研究进展

张继东a*(), 刘鸿泽a, 孟丽b   

  1. a安康学院化学化工学院 安康 725000
    b 中国富硒产业研究院 农业农村部富硒产品开发与质量控制重点实验室 安康 725000
  • 收稿日期:2019-03-04 出版日期:2019-11-25 发布日期:2019-06-19
  • 通讯作者: 张继东 E-mail:akuzjd@aku.edu.cn
  • 基金资助:
    陕西省科技厅重点(2018PT-31);安康市主导产业重大科研攻关(2016AKZDCY002);安康学院博士启动基金(2018AYQDZR06);农业部富硒产品开发国家地方联合工程实验室开放课题(Se-2018B02);陕西省大学生创新创业训练计划(201839032)

Research Progress in the Fluorescent Probes for Alkaline Phosphatase

Zhang Jidonga*(), Liu Hongzea, Meng Lib   

  1. a School of Chemistry & Chemical Engineering, Ankang Univerisity, Ankang 725000
    b Key Laboratory of Se-Enriched Products Development and Quality Control of Ministry of Agriculture, Se-Enriched Products Research Institute of China, Ankang 725000
  • Received:2019-03-04 Online:2019-11-25 Published:2019-06-19
  • Contact: Zhang Jidong E-mail:akuzjd@aku.edu.cn
  • Supported by:
    the Key Projects of Shaanxi Provincial Science & Technology Department(2018PT-31);the Major Scientific Research Projects of the Leading Industry of Ankang City(2016AKZDCY002);the Doctor's Initial Funding of Ankang University(2018AYQDZR06);the Key Laboratory of Se-Enriched Products Development and Quality Control, Ministry of Agriculture(Se-2018B02);the Shaanxi Provincial Innovation Experiment Program for University Students(201839032)

Alkaline phosphatase (ALP) is an important enzyme for various mammalian tissues. As a biomarker and diagnostic indicator, ALP provides important information for the applied research of molecular biology and the treatment of human diseases. Due to its reliability of information in human health, the research on fluorescence detection as important detection method has become intense in recent years. The fluorescent chemosensors are categorized by different luminous feature involving excitedstate intramolecular proton transfer (ESIPT) and intramolecular charge transfer (ICT) chemosensors, aggregation-induced luminescent molecules (AIE), diminishes the electron donating ability (D d-E) and disruption of the π conjugated systems (D π-C), inner filter e?ect (IFE) chemosensors, and other sensing systems. In the end, the development tendency of the sensing ensembles for ALP is prospected.

Key words: alkaline phosphatase, fluorescence detection, biological imaging, aggregation-induced emission