Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 969-982.DOI: 10.6023/cjoc202007020 Previous Articles     Next Articles



夏玉杰a, 何丹丹a, 伍婉卿a,b,*()   

  1. a 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510640
    b 华南理工大学 发光材料与器件国家重点实验室 广州 510640
  • 收稿日期:2020-07-07 修回日期:2020-09-01 发布日期:2020-10-12
  • 通讯作者: 伍婉卿
  • 基金资助:

Recent Advances for Hydration Reaction of Nitriles in Different Catalytic Systems

Yujie Xiaa, Dandan Hea, Wanqing Wua,b,*()   

  1. a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
    b State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640
  • Received:2020-07-07 Revised:2020-09-01 Published:2020-10-12
  • Contact: Wanqing Wu
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    National Natural Science Foundation of China(22071063)

Nitriles can be used to construct new carbon-carbon and carbon-hetero bonds which result in diverse products. Among them, amide groups can be found in a large variety of drugs, pesticides, natural products and key intermediates in organic synthesis. Among all the methods reported for the synthesis of amides, hydration reaction of nitriles has become one of the most widely used methods to obtain primary amides in both academia and industry. Conventional nitrile hydration generally involves the use of strong acids and bases which would cause some problems such as low yields, poor reaction selectivity and over hydrolysis of products to carboxylic acids. To overcome these disadvantages, achieve the hydration of nitriles efficiently and meet the requirements of green chemistry, different catalytic systems have been successfully developed, including transition metal complex catalysts, metal cationic catalysts, metal nanoparticle catalysts, ionic liquid catalysts and other types of catalysts. The hydration reaction of nitriles in these catalytic systems is reviewed and summarized, and the development prospect of this field is prospected.

Key words: nitrile, catalytic system, hydration reaction, amide