关键词: 中间体, 环氧化反应, 酯化, 羧酸酯, 立体选择性, 环氧化物, 环氧化物, 醛, 庚酸 P, 二十碳四烯酸 P

For the preparation of the key synthetic intermediate I of leukotriene A4, some asym. epoxidn. methods for 7-chiral 5-heptenoic acid derivatives have been evaluated. The cis-olefin II prepared from D-gluceraldehyde could be selectively hydroxylactonized. The mesylate of the 6-hydroxy compound III was treated with NaOMe to afford the desired (5S,6R)-epoxide IV. Deprotection of the diol group and cleavage with sodium periodate in one pot gave I.

Key words: INTERMEDIATE, EPOXIDATION REACTION, ESTERIFICATION, CARBOXYLIC ACID ESTER, STEREOSELECTIVITY, EPOXIDE, EPOXIDE, ALDEHYDES, HEPTANOIC ACID P, EICOSATETRAENOIC ACID P