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化学学报
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化学学报 ›› 2001, Vol. 59 ›› Issue (10): 1831-1834. 上一篇    下一篇

研究论文

手性双胺双膦-铱体系催化芳香酮的高对映选择性氢转移氢化

唐纯良;李岩云;潘恩德;章慧;周朝晖;高景星   

  1. 厦门大学固体表面物量化学国家重点实验室化学系
  • 发布日期:2001-10-15

Highly enantioselective transfer hydrogenation of aromatic ketones catalyzed by chiral diaminodiphosphine-iridium (I)complexes

Tang Chunliang;Li Yanyun;Pan Ende;Zhang Hui;Zhou Chaohui;Gao Jingxing   

  • Published:2001-10-15

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514

被引次数

4 | 4

在异丙醇溶液中，从[Ir(COD)Cl]2和C2-对称的手性双胺双膦配体原位制备了手性能-Ir(Ⅰ)配合物，并直接用于催化几种芳香酮的不对称氢转移氢化。结果表明，该配合物是异丙基苯基酮不对称转移氢化的优秀催化剂，当底物酮与催化剂的摩尔比(S/C)为1200:1时，在室温下反应4h后，得到相应的手性芳香醇的转化率和对映选择性分别高达98%和98%ee.

关键词: 铱络合物, 膦, 酮, 芳香族化合物, 氢化, 氢转移, 催化反应

Enantioselective transfer hydrogenation of a range of aromatic ketones in 2-propanol catalyzed by chiral Ir(Ⅰ) complexes, prepared in situ from [Ir(COD)Cl]2 and C2- symmetric diaminodiphosphine ligand. The complex acts as an excellent catalyst precursor in asymmetric transfer hydrogenation of isobutyrophenone, leading to optically active alcohol up to 98% yield and 98% ee after 4 h at 25℃ (S/C=1200) 。

Key words: IRIDIUM COMPLEX, PHOSPHINE, KETONE, AROMATIC COMPOUNDS, HYDROGENATION, HYDROGEN TRANSFER, CATALYTIC REACTION

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