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化学学报
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化学学报 ›› 1995, Vol. 53 ›› Issue (3): 269-274. 上一篇    下一篇

研究论文

反相液相色谱中溶质保留与溶剂化结构参数间的定量关系

邹汉法;张玉奎;洪名放;舒玉瑛;卢佩章   

  1. 中国科学院大连化学物理研究所;中国科学院国家色谱研究分析中心
  • 发布日期:1995-03-15

Relationship between retention values and solvatochromic parameters in reversed-phase liquid chromatography

ZOU HANFA;ZHANG YUKUI;HONG MINGFANG;SHU YUYING;LU PEIZHANG   

  • Published:1995-03-15

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本文研究了等度条件下反相液相色谱中溶质保留与溶剂化结构参数间的定量关系;考察了反相液相色谱保留值变化规律式lnk'=a+cC~b中参数a.c 与溶剂化结构参数间的定量关系,结果表明能较好地预测等度和不同冲洗剂组成下溶质的保留值,将乙腈-水和甲醇-水冲洗剂下的a.c值定量关联,表明在考虑溶质的氢键作用参数后,其相关性有所提高.

关键词: 结构参数, 水, 甲醇, 溶质, 乙腈, 保留值, 反相液相色谱, 溶化剂, 构效定量关系

Quant. relation between the retention values, the parameters a and c in retention equation lnk' = a + cCb and the solvatochromatic parameters in reversed-phase liquid chromatog. (RP-HPLC) were studied. The capacity factors of polar and nonpolar solutes at different organic modified concentration can be predicted by the solvatochromatic parameters through the prediction of parameters a and c. From the quant. relations of parameters a and c between the acetonitrile/water and methanol/water mobile phases, the hydrogen bonding solvatochromatic parameters play a significant role in improvement of the quant. relation.t

Key words: STRUCTURE PARAMETER, WATER, METHANOL, SOLUTE, ACETONITRILE, RETENTION-VALUE

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