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化学学报
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化学学报 ›› 1994, Vol. 52 ›› Issue (12): 1218-1220. 上一篇    

研究论文

二取双恶唑啉衍生物的合成及其在不对称环丙烷化反应中的应用

杨智才;钟民;陈良   

  1. 华东师范大学化学系
  • 发布日期:1994-12-15

Synthesis of bis-oxazolines and the application in asymmetic cyclopropanation

YANG ZHICAI;ZHONG MIN;CHEN LIANG   

  • Published:1994-12-15

PDF

544

被引次数

6

通过双亚氨酸盐酸盐与手性胺醇反应简便地合成了二取代双恶唑啉衍生物, 并将其与铜配位运用于重氮醋酸酯对烯烃的不对称环丙化反应, 不对称诱导反应光学产物收率最高达95%d.e.

关键词: 烯烃, 环丙烷 P, 环化, 氨基醇, 恶唑啉 P, 亚胺酸 P, 不对称反应

Bisoxazolines I (R1, R2 = PhCH2, H; Ph3COCH2, 4-O2NC6H4; HOCH2, 4-O2NC6H4) were easily prepared from di-Et propanediimidoate dihydrochloride and chiral amino alcs. R1CH(NH2)CH(OH)R2. These bisoxazolines were successfully applied to the reaction of alkyl diazoacetate with olefin to give optically active alkyl cyclopropanecarboxylate. The highest enantioselectivity achieved 95% d.e. in the catalytic cyclopropanation of isobutene

Key words: ALKENE, CYCLOPROPANE P, CYCLIZATION, AMINO ALCOHOL

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