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化学学报
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化学学报 ›› 1990, Vol. 48 ›› Issue (11): 1127-1130. 上一篇    下一篇

研究论文

新型手性固定相的合成及其应用

詹正云;周良模   

  1. 中国科学院大连化学物理研究所
  • 发布日期:1990-11-15

Syntheses and their applications of some novel chiral stationary

ZHAN ZHENGYUN;ZHOU LIANGMO   

  • Published:1990-11-15

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本文采用了一种新的简便方法合成了四个新型手性固定相; N-十一碳-10-烯酰-L-缬氨酸-S-α-苯乙胺(手性-S-1)N-十一碳-10烯酰-L-缬氨酰-R-α-苯乙胺(手性-R-1)及生-S-α, 手性-S-3, 并对外消旋的α-β-氨基酸, 外消旋的α-β-羟基酸和含手性烃基的外消旋胺的进行了折分, 在四丁固定相中手性-S-1对上述对映体的折分选择性最好。

关键词: 氨基酸, 苯乙胺 P, 胺, 固定相, 羟基羧酸, 烯烃 P, 缬氨酸, 十一碳化合物, 消旋体拆分, 酰化合物

Four novel chiral stationary phases, N-undecenoyl-L-valyl-S(or R)-a-phenylethylamide(CSP-S-1 or CSP-R-1), N-pentadecyl-L-valyl-S-a-phenylethylamide (CSP-S-2) and N-octadecyl-L-valyl-S-a-phenylethylamide(CSP-S-3) were synthesized by a simple new method. Some racemic a- and b-amino acids, a- and b-hydroxy acids and amines with asym. alkyl group were resolved. The enantioselectivity of CSP-S-1 is the best one for their sepns.

Key words: AMINO ACID, PHENYLETHYLAMINE P, AMINES, STATIONARY PHASE, HYDROXYCARBOXYLIC ACIDS, ALKENE P, VALINE, C11 COMPOUNDS, MESOTOMY, ACYL COMPOUND

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