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封面介绍Liu, Liu Leo et al. on page 1025-1034: Cracking open the shell reveals a σ0π2-carbene “pearl” with an in-plane σ vacancy and an out-of-plane π lone pair. The four bubbles above depict four archetypes of inverted-state carbenes—cyclic di(imino)carbenes, di(boryl)carbenes, metal-coordinated cyclic di(phosphino)carbenes, and dicationic carbones—each expressing a distinct donor-acceptor balance. Together they highlight how tuning the environment unlocks σ0π2 carbenes as versatile platforms for small-molecule activation and next-generation ligand design. -
封面介绍Shi, Yuxiang & Zhang, Weixian et al. on page 1055-1071: Mechanochemistry emerges as a force-driven platform for environmental sustainability, enabling efficient resource recovery, pollutant remediation, and the creation of advanced functional materials. -
封面介绍Wang, Shaohua et al. on page 981-986: This study presents a novel strategy for constructing complex oxygen-containing tricyclic frameworks. The efficient and stereoselective synthesis of such architectures remains a significant challenge. Through a tandem ether α-C–H oxidation/polyene cyclization reaction, this work enables the direct conversion of simple, acyclic ethers into fused oxa-tricyclic 6/6/6 ring systems. The cover image embodies the innovation of harnessing tunable reactive intermediates and the potential application of this strategy in synthesizing core structures of natural products. -
封面介绍Hu, Hongguo & Yao, Wenbing et al. on page 1000-1005: The robust and efficient synthesis platform unlocks the clinical potential of neoantigen vaccines, paving a faster and more reliable path toward personalized cancer immunotherapy for a broader range of patients.
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