Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (2): 105-113.DOI: 10.6023/A19080301 Previous Articles     Next Articles



耿慧敏, 崔基炜, 郝京诚   

  1. 山东大学胶体与界面化学教育部重点实验室 济南 250100
  • 投稿日期:2020-01-11 发布日期:2020-01-13
  • 通讯作者: 崔基炜, 郝京诚;
  • 作者简介:耿慧敏,2018年博士毕业于北京理工大学,同年加入山东大学从事博士后研究,主要从事生物高分子凝胶材料的制备、性能研究及其生物医学应用;崔基炜,教授,博士生导师.2010年博士毕业于山东大学胶体与界面化学教育部重点实验室,2010至2016年在墨尔本大学从事博士后研究工作.研究领域主要包括高分子胶体与凝胶、生物与纳米材料的相互作用、药物和疫苗传输等;郝京诚,教授,博士生导师.1995年博士毕业于中国科学院兰州化学物理研究所,1997~2003年分别在日本、德国和美国从事博士后研究,主要研究方向是胶体与界面化学及其相关应用.
  • 基金资助:

Mussel-Inspired Hydrogels for Tissue Healing

Geng Huimin, Cui Jiwei, Hao Jingcheng   

  1. Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan 250100
  • Received:2020-01-11 Published:2020-01-13
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21603120, 21872085) and the Natural Science Foundation of Shandong Province (Nos. ZR2018ZA0547, ZR2019BB056).

Surgical sutures, staples and clips have been widely used for wound closure, tissue reconstruction and tissue adhesives are one of the versatile alternatives especially for friable tissues. Some synthetic and semisynthetic tissue adhesives are available elsewhere. However, there are some drawbacks, such as poor adhesion on wet substrates and potential toxicity, for the reported tissue adhesives. Fibrin glues as biological tissue adhesives are effective hemostatic agents while presenting relatively weak tensile and adhesion strengths and being expensive. Biomimetic adhesives as tissue adhesives, hemostatic agents, or tissue sealants have attracted great attention for clinical operations in last three decades. However, engineering of bio-adhesive materials with good water resistance, high adhesive strength, and good biocompatibility and multi-functionality remains a challenge for tissue healing. Since the first report of mussel-inspired surface chemistry for functional coatings of polydopamine by the Messersmith group in 2007, materials containing plenty of phenolic hydroxyl groups have been widely used in medical applications, food, cosmetics, water treatment and so on, due to the antioxidant, antibacterial, and anti-inflammatory effects of polyphenols. Polyphenol-based hydrogel is an ideal bio-adhesive material due to its good tissue adhesion even on wet substrates, hemostatic and antimicrobial capabilities. Moreover, these hydrogels with porous structures have similar physiochemical properties to that of natural extracellular matrix and different shapes from nanometer to centimeter scales can be remolded to seal irregular defects on tissues. In this review, we report the recent progress of the engineering of polyphenol-synthetic polymer hydrogels, polyphenol-biomacromolecule hydrogels, polyphenol-inorganic nanocomposite hydrogels, and polydopamine nanoparticle composite hydrogels, as well as their applications of tissue adhesives, hemostasis, antimicrobials for wound closure and tissue regeneration. The challenges as well as prospects for future development of polyphenol-based tissue adhesives, sealants, hemostatic agents are also summarized and discussed, which is helpful to promote the next generation of tissue adhesives for biomedical applications.

Key words: polyphenol, hydrogel, bio-adhesive, hemostasis, tissue healing