Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (12): 1739-1753.DOI: 10.6023/A23090402 Previous Articles     Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑



张恒杰, 柳坤锐, 陈显春*(), 顾志鹏*(), 李乙文*()   

  1. 四川大学高分子科学与工程学院 高分子材料工程国家重点实验室 成都 610065
  • 投稿日期:2023-09-03 发布日期:2023-10-22
  • 作者简介:

    张恒杰, 四川大学高分子科学与工程学院李乙文教授课题组在读博士生. 于2020年和2023年分别获得青岛科技大学工学学士和四川大学工学硕士学位, 主要研究方向为智能光响应生物粘附材料的制备及应用.

    柳坤锐, 四川大学高分子科学与工程学院在读硕士生. 于2020年获得四川大学工学学士学位, 主要研究方向为基于天然高分子的生物粘附材料.

    陈显春, 副教授, 博士生导师, 四川大学科研院重大项目与基地管理部副部长, 2010年6月获四川大学材料学博士学位. 主要研究兴趣包括无机/有机复合生物材料.

    顾志鹏, 四川大学高分子科学与工程学院特聘副研究员, 2009年和2014年在四川大学高分子科学与工程学院分别获得学士、博士学位; 2014年~2016年在四川大学华西临床医学院从事博士后研究; 2016年~2019年在中山大学生物医学工程学院任特聘副研究员(合作带头人: 吴钧教授); 现在四川大学高分子科学与工程学院李乙文课题组, 目前研究领域主要集中在利用多酚化学在不同维度实现功能材料的构筑合成、材料加工及其在抗氧化领域的应用基础研究.

    李乙文, 四川大学高分子科学与工程学院教授, 国家杰出青年科学基金获得者, 2008年在中国科学技术大学获得学士学位; 2013年在美国阿克伦大学获得博士学位; 2013年~2016年在美国加州大学圣地亚哥分校从事博士后研究. 自2016年起在四川大学开始独立教学与科研工作, 主要致力于人造黑色素和功能多酚等新概念大分子材料的基础与转化研究.

  • 基金资助:
    项目受国家重点研发计划(2022YFB3804400); 国家自然科学基金(52173132)

Design and Application of Light Responsive Smart Bio-adhesive Materials

Hengjie Zhang, Kunrui Liu, Xianchun Chen(), Zhipeng Gu(), Yiwen Li()   

  1. State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065
  • Received:2023-09-03 Published:2023-10-22
  • Contact: *E-mail:;;; Tel.: 028-85401066
  • About author:
    ★Dedicated to the 90th anniversary of Acta Chimica Sinica.
  • Supported by:
    National Key R&D Program of China(2022YFB3804400); National Natural Science Foundation of China(52173132)

Smart bio-adhesive materials are a new type of adhesive that could adhere to tissue surface through bio-adhesion covalent and noncovalent interactions, including hydrogen bonding, electrostatic interactions, cation-π interactions, π-π interactions, Michael addition, Schiff base, amide bond and so on, which usually has a specific response to specific external and internal stimuli, such as in vivo (chemical components, pH, oxidants and enzymes) and in vitro (temperature, ultrasound, light) trigger types. Additionally, smart bio-adhesive materials have attracted great attention in clinical surgical applications due to its numerous advantages, including fast hemostasis, good biocompatibility, strong bio-adhesion, convenient use, simple preparation, excellent repair promoting performance and smart response effect. Among them, light responsive bio-adhesive materials, including ultraviolet (UV) light, visible and near infrared (NIR) light responsive bio-adhesive materials, have unique advantages such as non-contact, spatiotemporal regulation, strict tailoring, accurate positioning, simple operation and remote control, and which have been widely used in wound healing, tissue repair, antibacterial therapy, 3D printing, biomimetics and software devices, cell coating and culture, bio-production and patterning, and other applications. In addition to the widely used UV light responsive bio-adhesive materials, visible and NIR light bio-adhesive materials have received great attention in light responsive biomedical materials and bio-adhesive applications due to its unique features, including excellent and long tissue penetration depth, high stability, low damage to cells and human tissues, and low energy dosage. In this paper, response type of smart bio-adhesive materials is reviewed, and the research progress of UV light, visible and NIR light response bio-adhesive materials in recent years is mainly introduced, including classification, performance and specific application in biomedical field.

Key words: smart response, bio-adhesive material, biological hemostasis, light control design, hydrogel