Acta Chimica Sinica ›› 2021, Vol. 79 ›› Issue (3): 238-256.DOI: 10.6023/A20090441 Previous Articles     Next Articles



李佳欣a, 李蓓b, 王纪康a, 何蕾a,*(), 赵宇飞a,*()   

  1. a 北京化工大学化学学院 化工资源有效利用国家重点实验室 北京 100029
    b 澳大利亚昆士兰大学生物工程与纳米技术国家研究所 澳大利亚布里斯班 QLD 4072
  • 投稿日期:2020-09-23 发布日期:2020-12-24
  • 通讯作者: 何蕾, 赵宇飞
  • 作者简介:

    李佳欣, 北京化工大学在读博士, 2017 年 6 月于北京化工大学理学院应用化学专业获得学士学位, 随后加入北京化工大学化工资源有效利用国家重点实验室宋宇飞教授课题组, 主要研究方向为水滑石光催化精细化学品的合成.

    李蓓博士, 2015年6月于北京化工大学化工资源有效利用国家重点实验室卫敏课题组获得硕士学位, 随后加入澳大利亚昆士兰大学生物工程与纳米技术国家研究所Zhi Ping (Gordon) Xu课题组, 并于2019年9月获得博士学位. 主要研究方向为多功能纳米材料的生物医学应用.

    何蕾博士, 北京化工大学副教授、硕士生导师. 主要致力于疾病相关生物靶分子的药物设计、仿生光电催化等交叉领域的研究.

    赵宇飞, 北京化工大学化学学院教授, 博士生导师. 入选中国科协“青年人才托举工程”计划, 2019年度国家自然科学基金优秀青年科学基金获得者.
    工作围绕水滑石基二维插层材料的可控合成及精细结构表征, 面向高值精细化学品的光/电催化合成. 近年来以第一/通讯作者在Chem. Soc. Rev., J. Am. Soc. Chem., Angew Chem., Adv. Mater., Chem, Joule, Ind. Eng. Chem. Res.等期刊上发表SCI收录论文30余篇; 累计SCI他引4500余次; 5篇入选ESI高被引论文, 已授权国家发明专利19项.

  • 基金资助:
    项目受国家自然科学基金(21878008); 项目受国家自然科学基金(22007004); 北京自然科学基金(2182047); 北京自然科学基金(2202036); 中央高校基本科研业务费专项资金(buctrc202010)

Recent Advances in Layered Double Hydroxides and Their Derivatives for Biomedical Applications

Jiaxin Lia, Bei Lib, Jikang Wanga, Lei Hea(), Yufei Zhaoa()   

  1. a State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029
    b Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane QLD 4072, Australia
  • Received:2020-09-23 Published:2020-12-24
  • Contact: Lei He, Yufei Zhao
  • About author:
    † These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(21878008); National Natural Science Foundation of China(22007004); Natural Science Foundation of Beijing(2182047); Natural Science Foundation of Beijing(2202036); Fundamental Research Funds for the Central Universities(buctrc202010)

With the awareness of human and public health increasing, biomedical research has been paid more and more attention. 2D intercalation materials with versatile physicochemical advantages have attracted extensive interest in biomedical applications. Layered double hydroxides (LDHs), as a class of typical 2D materials, have been widely utilized as various multi-function materials and exhibited great promise in biomedical applications. The general chemical formula of LDHs can be described as [M2+ 1–x M3+ x (OH)2]q+(An)q/n·yH2O, where M2+ and M3+ refer to divalent and trivalent mental cations, respectively, and An is an exchangeable anion, including inorganic, organic, biological compound, and even gene. LDHs have attracted a great attention in the field of biomaterials due to their good biocompatibility, pH sensitivity, biodegradability, high intracellular delivery efficacy and low cost, etc. In this review, we summarize the development of LDHs and related nanocomposites for biomedical applications including sterilization, cancer therapy, bioimaging, etc. In general, the LDH-based sterilization materials can be divided into four categories. The first type is the pristine LDHs and their derivatives named mixed mental oxides (MMO). The second type is organo-modified LDHs nanostructures, including surface modified LDHs and interlayer assembled biomaterials, which embed antibacterial agents or other biomolecules in the interlayer spaces. The last two are enzyme immobilized LDHs and Ag NPs deposited LDHs, respectively. In addition to sterilization, LDHs have also been applied to cancer diagnosis and therapy. We mainly introduce three types of cancer monotherapy, including photodynamic, photothermal and chemodynamic therapy. Moreover, cancer combination therapy and bioimaging for cancer diagnosis are also discussed. Furthermore, the large-scale synthesis of LDH-based materials plays a fundamental role in the potential biomedical applications in the future. Therefore, we summarize the feasible methods of large-scale production of LDHs reported in recent years. Among them, the SNAS (separate nucleation and aging steps) method with a simple and quick operation, and has realized the industrial scale-up production of LDHs. Finally, we also discussed the future challenges and opportunities of LDH-based biomaterials.

Key words: layered double hydroxides, biomedical, antibacterial, cancer therapy, large-scale production