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Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (22): 2277-2281. Previous Articles     Next Articles

桑色素及其配合物与DNA作用的比较

王流芳1, 宋玉民2, 冯亚非3, 张歧1,4, 王印月1   

  1. 1. 兰州大学功能有机分子化学国家重点实验室, 兰州, 730000;
    2. 西北师范大学化学化工学院, 兰州, 730070;
    3. 湛江海洋大学理学院, 湛江, 524088;
    4.海南大学理工学院, 海口, 570228
  • 投稿日期:2004-11-03 修回日期:2004-07-16 发布日期:2014-02-17
  • 通讯作者: 王流芳,E-mail:wanglf@lzu.edu.cn;Fax:0931-8912582. E-mail:wanglf@lzu.edu.cn
  • 基金资助:
    甘肃省自然科学基金(No.ZSO21-A25-005-Z)及国家自然科学基金(No.50272027)资助项目.

Comparison between the Interactions of Morin and Its Complexes with DNA

WANG Liu-Fang1, SONG Yu-Min2, FENG Ya-Fei3, ZHANG Qi1,4, WANG Yin-Yue1   

  1. 1. State Key Laboratory of Functional Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070;
    3. College of Science, Zhanjiang Ocean University, Zhanjiang 5240;
    4. College of Science and Engineering, Hainan University, Haikou 570228
  • Received:2004-11-03 Revised:2004-07-16 Published:2014-02-17

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The interactions of Morin (2',3,4',5,7-pentahydroxyflavone) and its Zn(Ⅱ), Cu(Ⅱ), or Co(Ⅱ)-complex with calf thymus DNA have been studied by using spectral, viscometric and electrochemical methods. And there is a comparison between the interactions of Morin and its Co(Ⅱ), Cu(Ⅱ), or Zn(Ⅱ)-complexes with DNA. The complexes of Zn(Ⅱ) and Cu(Ⅱ) have the same spectral characteristics, which is different from that of Morin and Co(Ⅱ)-complex in the presence of DNA. The electrochemical behavior of Co(Ⅱ)-complex is the same as that of Cu(Ⅱ)-complex, but different from that of Zu(Ⅱ)-complex with the DNA addition. The relative viscosity of DNA increased with the addition of Zu(Ⅱ)-, Cu(Ⅱ)- or Co(Ⅱ)-complex. The results suggest that the Co(Ⅱ)-complex binds to DNA in a part-intercalating mode. This may be one of the reasons that the antitumour activity of Co(Ⅱ)-complex is weaker than that of Cu(Ⅱ) and Zn(Ⅱ)-complexes, which bind to DNA in intercalating mode.

Key words: complex, DNA, binding mode