有机化学 ›› 2012, Vol. 32 ›› Issue (02): 400-403 .DOI: 10.6023/cjoc1104143 上一篇    下一篇

研究简报

无溶剂条件下方便、有效的方法合成3-氰基-2-吡啶酮衍生物

荣良策a,b, 刘丽华a, 殷姗b, 夏盛b, 魏贤勇a, 宗志敏a   

  1. a 中国矿业大学化工学院 徐州 221008;
    b 徐州师范大学化学化工学院 徐州 221116
  • 收稿日期:2011-04-14 修回日期:2011-07-21 发布日期:2012-03-09
  • 通讯作者: 魏贤勇 E-mail:lcrong@xznu.edu.cn or lcrong2005@yahoo.com
  • 基金资助:

    江苏省高校自然科学基础研究基金(No. 08KJB150017)、徐州师范大学科研平台(No. 10XLS02)资助项目.

A Facile and Efficient Synthesis of 3-Carbonitrile Pyridin-2(1H)-one Derivatives under Solvent-Free Conditions

Rong Liangcea,b, Liu Lihuaa, Yin Shanb, Xia Shengb, Wei Xianyonga, Zong Zhimina   

  1. a School of Chemical Engineering and Technology, China University of Mining and Technology,Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Xuzhou Normal University Xuzhou 221116
  • Received:2011-04-14 Revised:2011-07-21 Published:2012-03-09
  • Supported by:

    Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017), and the Research Platform Foundation of Xuzhou Normal University (No. 10XLS02).

芳醛、丙酮和氰乙酰胺为原料, 氢氧化钠为催化剂, 在无溶剂条件下加热反应有效地合成2-吡啶酮衍生物, 本方法具有反应时间短、条件温和、处理简单和环境友好等优点.

关键词: 2-吡啶酮, 杂环, 无溶剂反应, 合成

An efficient and convenient method for the preparation of 3-carbonitrile pyridin-2(1H)-one derivative by the one-pot reaction of aromatic aldehydes, acetones and 2-cyanoacetamide in the presence of sodium hydroxide under solvent- free condition was reported. This method has the advantages of excellent yields, mild reaction conditions, easy work-up, and environmentally friendly procedure.

Key words: pyridin-2(1H)-one, heterocycle, solvent-free reaction, synthesis