有机化学 ›› 2013, Vol. 33 ›› Issue (06): 1186-1194.DOI: 10.6023/cjoc201303056 上一篇    下一篇

综述与进展

斯替宁碱的合成方法研究进展

陈静波, 陈景超, 谢彦, 刘娜娜, 刘丹丹, 张洪彬   

  1. 云南大学自然资源药物化学教育部重点实验室 昆明 650091
  • 收稿日期:2013-03-31 修回日期:2013-05-21 发布日期:2013-05-24
  • 通讯作者: 张洪彬 E-mail:zhonghb@ynu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21062029, 20562013及20925205)资助项目.

Research Progress on the Synthesis of Stenine

Chen Jingbo, Chen Jingchao, Xie Yan, Liu Nana, Liu Dandan, Zhang Hongbin   

  1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan University, Kunming 650091
  • Received:2013-03-31 Revised:2013-05-21 Published:2013-05-24
  • Supported by:

    Project supported by the the National Natural Science Foudation of China (Nos.21062029, 20562013, 20925205).

具有1H-吡咯并[1,2-a]氮杂和多取代全氢吲哚结构的斯替宁碱是百部生物碱的代表性结构, 其多环结构和连续的七个手性中心对不对称合成化学极具挑战性.按斯替宁碱合成中使用的关键方法分类, 对斯替宁碱的合成研究进展进行了综述.

关键词: 斯替宁, 消旋合成, 不对称合成

The alkaloid stenine which has a representative pyrrolo[1,2-a]azepine nucleus and a highly substituted perhydroindole ring system is unique among Stemona alkaloids.The polycyclic system and the seven contiguous stereogenic centers in (-)-stenine present a challenge for asymmetric organic synthesis.Progresses toward the synthesis of stenine are reviewed in terms of the key strategies employed.

Key words: stenine, racemic synthesis, asymmitric synthesis