有机化学 ›› 2013, Vol. 33 ›› Issue (11): 2407-2411.DOI: 10.6023/cjoc201306013 上一篇    下一篇

研究论文

离子液体中钯催化炔与烯丙醇的交叉偶联反应

李建晓, 杨少容   

  1. 华南理工大学化学与化工学院 广州 510640
  • 收稿日期:2013-06-07 修回日期:2013-07-03 发布日期:2013-07-10
  • 通讯作者: 杨少容 E-mail:lisryang@scut.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21102047 )和中央高校基金(No. 2012ZM0037)资助项目.

Pd-Catalyzed Cross-Coupling Reaction of Alkynes with Allylic Alcohol in Ionic Liquids

Li Jianxiao, Yang Shaorong   

  1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
  • Received:2013-06-07 Revised:2013-07-03 Published:2013-07-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21102047) and the Fundamental Research Funds for the Central Universities (No. 2012ZM0037).

发展了一种在室温条件下,以PdBr2为催化剂,以[Bmim]Br/HBraq为溶剂,炔烃与烯丙醇进行交叉偶联反应的新方法,以中等及优良的产率(61%~93%)合成了溴代-1,4-二烯衍生物. 反应表现出较高的区域选择性和立体选择性. 催化体系可以循环使用4次,并且保持活性不变.

关键词: 离子液体, 钯催化, 炔烃, 烯丙醇, 交叉偶联

A Pd-catalyzed method was developed for cross-coupling reaction of a wide range of alkynes with allylic alcohol in ionic liquids. In the presence of PdBr2, [Bmim]Br and HBraq, the cross-coupling products can be obtained in moderate to good yields, and the reaction displayed high regio-and stereo-selectivities. The catalyst system could be recycled four times without loss of activity.

Key words: ionic liquid, palladium-catalyst, alkyne, allylic alcohol, cross-coupling reaction