双模式Lewis Acid介导串联环化反应在天然产物全合成中的应用

doi:10.6023/cjoc201307010

摘要/Abstract

综述了近年来我们研究小组在双模式路易斯酸介导的串联反应研究方面的进展. 利用双模式路易斯酸的特殊性质, 发展了三种新的串联环化反应, 并通过拓展反应起始底物的方式对方法学的底物适用性进行了探究, 最后, 将方法学应用至天然产物全合成的研究之中.

关键词: 双模式路易斯酸, 串联环化反应, 天然产物全合成

This account covers the recent advance of the dual-mode Lewis acid induced cascade cyclization reactions in our group. Taking advantage of the special properties of the dual-mode Lewis acids, three new types of cascade reactions have been developed. Moreover, the applicability of the cascade cyclization reactions was explored through studying the scope of substrates. Finally, these reactions were employed for total syntheses of natural products.

Key words: dual-mode Lewis acid, cascade cyclization reaction, total syntheses of natural product

引用此文

朱礼志, 杜广延, 杨炜, 闵龙, 刘小卒, 黄双平, 韩叶俭, 李志成. 双模式Lewis Acid介导串联环化反应在天然产物全合成中的应用[J]. 有机化学, 2013, 33(10): 2031-2045.

Zhu Lizhi, Du Guangyan, Yang Wei, Min Long, Liu Xiaozu, Huang Shuangping, Han Yejian, Lee Chi-Sing. Applications of Dual-Mode Lewis Acids Induced Cascade Cyclization Reactions in Natural Product Synthesis[J]. Chin. J. Org. Chem., 2013, 33(10): 2031-2045.

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