有机化学 ›› 2017, Vol. 37 ›› Issue (12): 3186-3190.DOI: 10.6023/cjoc201705017 上一篇    下一篇

研究论文

ZnAl-BrO3--LDHs/KBr溴源在苯胺类化合物选择性氧化溴代的应用

王力耕, 陈璐焌, 章华隆, 余琴   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2017-05-11 修回日期:2017-07-07 发布日期:2017-09-08
  • 通讯作者: 王力耕 E-mail:wanglg@zjut.edu.cn

Selective Oxidative Bromination of Anilines Using Potassium Bromide and ZnAl-BrO3--LDHs

Wang Ligeng, Chen Lujun, Zhang Hualong, Yu Qin   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2017-05-11 Revised:2017-07-07 Published:2017-09-08
  • Contact: 10.6023/cjoc201705017 E-mail:wanglg@zjut.edu.cn

以醋酸/水为溶剂,用溴酸根插层的水滑石和溴化钾为溴源,室温下完成对苯胺类化合物的选择性氧化溴代反应.成功合成苯胺类化合物的单溴代和多溴代的目标产物,并获得较高产率.考察了底物结构及反应条件对反应选择性的影响.应用该溴源试剂,环境友好,操作简单,产率高,是一种合成溴代苯胺类化合物的新途径.

关键词: 苯胺类, 卤化, 选择性, 芳香取代

The oxidative bromination of anilines was realized with ZnAl-BrO3--LDHs/KBr as the bromine source at ambient temperature in acidic medium (AcOH/H2O). High yields of monobrominated or polybrominated anilines were achieved for a wide range of anilines. Both the substrate structure and the reaction conditions will significantly influence the reaction selectivity. The use of inexpensive reagents, environmentally benign and operationally simple process, and excellent yields make it a good alternative to the synthesis of bromoanilines.

Key words: anilines, halogenation, selectivity, aromatic substitution