有机化学 ›› 2018, Vol. 38 ›› Issue (11): 3137-3140.DOI: 10.6023/cjoc201804028 上一篇    下一篇

研究简报

异叶三宝木枝叶中一个新的Stemodane型二萜类化合物

刘艳萍a,b, 张项林a,b, 牛海渊a,b, 官春艳a,b, 孙福康a,b, 杨柳萌c, 付艳辉a,b   

  1. a 海南师范大学 热带药用植物化学教育部重点实验室 海口 571158;
    b 海南师范大学 南药资源产业化关键技术研究海口市重点实验室 海口 571158;
    c 中国科学院昆明动物研究所 中国科学院动物模型与人类疾病机理重点实验室 昆明 650223
  • 收稿日期:2018-04-15 修回日期:2018-06-03 发布日期:2018-06-29
  • 通讯作者: 付艳辉 E-mail:fuyanhui80@163.com
  • 基金资助:

    海南省重点研发计划(No.ZDYF2016221)、海口市重点研发计划(No.2017050)、国家自然科学基金(Nos.21662011,31660097)和教育部创新发展团队项目(No.IRT-16R19)资助项目.

A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus

Liu Yanpinga,b, Zhang Xianglina,b, Niu Haiyuana,b, Guan Chunyana,b, Sun Fukanga,b, Yang Liumengc, Fu Yanhuia,b   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158;
    b Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158;
    c Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223
  • Received:2018-04-15 Revised:2018-06-03 Published:2018-06-29
  • Supported by:

    Project supported by the Key Research and Development Project of Hainan Province (No. ZDYF2016221), the Key Research and Development Project of Haikou City (No. 2017050), the National Natural Science Foundation of China (Nos. 21662011, 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19).

综合运用硅胶柱色谱、反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱以及制备型高效液相色谱等色谱分离技术对大戟科三宝木属植物异叶三宝木Trigonostemon heterophyllus枝叶中的化学成分进行了系统研究,从其枝叶的85%乙醇提取物中分离得到了8个二萜类化合物.采用多种波谱鉴定技术确定了这些化合物的化学结构.其中一个化合物为新的罕见的stemodane型二萜类化合物,七个化合物为首次从三宝木属植物中分离得到的化合物.所有化合物的体外细胞毒活性评价结果表明,它们对五种肿瘤细胞株(HL-60、A549、SMMC-7721、MCF-7和SW480)均显示出了较为显著的体外生长抑制活性,它们的细胞毒活性与抗肿瘤阳性对照药顺铂的活性相当.

关键词: 三宝木属, 异叶三宝木, stemodane型二萜, 细胞毒活性

A new stemodane diterpenoid, trigoheterone A (1), together with seven known diterpenoids, was isolated from the stems and leaves of Trigonostemon heterophyllus. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time. The cytotoxicities of all isolated compounds were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). As a result, eight compounds exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.

Key words: Trigonostemon, Trigonostemon heterophyllus, stemodane diterpenoid, cytotoxicities