有机化学 ›› 2019, Vol. 39 ›› Issue (4): 961-973.DOI: 10.6023/cjoc201809031 上一篇    下一篇

综述与进展

贝克曼重排的研究新进展

张健a, 刘园园b, 冯维春c, 武玉民a   

  1. a 青岛科技大学化工学院 青岛 266042;
    b 青岛科技大学化学与分子工程学院 青岛 266042;
    c 青岛科技大学山东化工研究院 济南 250014
  • 收稿日期:2018-09-26 修回日期:2018-11-06 发布日期:2018-12-17
  • 通讯作者: 张健 E-mail:jian8552@163.com
  • 基金资助:

    山东省高校科研计划(No.J18KA102)和山东省自然科学基金(No.ZR201807060818)资助项目.

Recent Progress in Beckmann Rearrangement

Zhang Jiana, Liu Yuanyuanbb, Feng Weichuncc, Wu Yumina   

  1. a College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao 266042;
    b College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042;
    c Chemical Technology Academy of Shandong Province, Qingdao University of Science & Technology, Qingdao 250014
  • Received:2018-09-26 Revised:2018-11-06 Published:2018-12-17
  • Contact: 10.6023/cjoc201809031 E-mail:jian8552@163.com
  • Supported by:

    Project supported by the Science and Technology Development Project in University of Shandong Province (No.J18KA102),the Natural Science Foundation of Shandong Province of China (No.ZR201807060818).

酰胺类化合物广泛存在于天然产物、药物和生物活性分子中,酰胺键的形成反应是有机化学最重要的反应之一,贝克曼重排反应是合成伯酰胺和仲酰胺的重要方法.近年来,许多新的催化体系被建立,包括从醛、酮甚至是醇出发的一锅法反应.主要综述了近五年来贝克曼重排的研究进展及其应用.

关键词: 贝克曼重排, 酰胺, 合成,

Amide motifs are prevalent structures found in natural products, pharmaceuticals, and bioactive compounds. Amide bond formations are the most important transformations in organic chemistry. Beckmann rearrangement is a significant method for the synthesis of primary and secondary amides. Recently, diversified new catalytic protocols were developed, including one-pot reaction from the corresponding aldehydes and ketones, or even from alcohols. The progress and applications of Beckmann rearrangement in recent five years are reviewed.

Key words: Beckmann rearrangement, amides, synthesis, oximes