有机化学 ›› 2021, Vol. 41 ›› Issue (9): 3710-3716.DOI: 10.6023/cjoc202104033 上一篇    下一篇

研究简报

无催化剂一锅法构建取代磺酰吡唑

马豪杰a,b, 周小强b,c, 韩波a, 李然a, 侯雪艳a, 姬星月a, 张玉琦a,*(), 黄国生b,*(), 王记江a   

  1. a 延安大学化学与化工学院 延安大学新能源与新功能材料重点实验室 陕西化学反应工程重点实验室 陕西延安 716000
    b 兰州大学功能有机分子化学国家重点实验室 兰州 730000
    c 渭南师范学院化学与材料学院 陕西渭南 714099
  • 收稿日期:2021-04-16 修回日期:2021-04-27 发布日期:2021-06-22
  • 通讯作者: 张玉琦, 黄国生
  • 基金资助:
    国家自然科学基金(21663032); 国家自然科学基金(31701679); 国家自然科学基金(22061041); 延安大学博士科研启动基金(YDBK2019-30); 延安大学博士科研启动基金(YDBK2015-11); 延安市高层次人才专项基金(2019-29); 延安大学大学生创新创业训练计划(D2019016); 陕西省科技厅自然科学基础研究基金(2019JQ-902); 陕西省教育厅自然科学专项研究基金(19JK0287)

A Catalyst-Free One-Pot Protocol for the Construction of Substituted Sulfonyl Pyrazoles

Haojie Maa,b, Xiaoqiang Zhoub,c, Bo Hana, Ran Lia, Xueyan Houa, Xingyue Jia, Yuqi Zhanga(), Guosheng Huangb(), Jijiang Wanga   

  1. a Key Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, Yan'an University, Yan'an, Shaanxi 716000
    b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000
    c College of Chemistry and Material, Weinan Normal University, Weinan, Shaanxi 714099
  • Received:2021-04-16 Revised:2021-04-27 Published:2021-06-22
  • Contact: Yuqi Zhang, Guosheng Huang
  • Supported by:
    National Natural Science Foundation of China(21663032); National Natural Science Foundation of China(31701679); National Natural Science Foundation of China(22061041); PhD Research Startup Foundation of Yan'an University(YDBK2019-30); PhD Research Startup Foundation of Yan'an University(YDBK2015-11); Municipal Special Fund of Yan'an for High-Level Talents(2019-29); Yan'an University Training Program of Innovation and Entrepreneurship for Undergraduates(D2019016); Natural Science Basic Research Program of Shaanxi Province(2019JQ-902); Scientific Research Program Funded by Shaanxi Provincial Education Department(19JK0287)

开发了一种新型有效的在无催化剂条件下由苯磺酰肼和戊烷-2,4-二酮构建取代吡唑的方法, 该方法具有官能团适用性好、步骤经济、操作简单、试剂便宜、反应条件温和及可进行按比例放大等优势.

关键词: 无催化剂, 磺酰吡唑, 戊烷-2,4-二酮, 苯磺酰肼

A novel and efficient protocol for the construction of substituted pyrazoles from benzenesulfonohydrazides and pentane-2,4-diones under catalyst-free conditions was developed. This protocol features excellent tolerance to a variety of functional groups, step economy, simple operation with inexpensive reagents, mild reaction conditions, and can be scaled-up.

Key words: catalyst-free, sulfonyl pyrazole, pentane-2,4-dione, benzenesulfonohydrazide