十元氮杂环化合物合成最新研究进展

doi:10.6023/cjoc202508004

摘要/Abstract

十元氮杂环化合物不仅是众多含氮生物碱的核心骨架, 也是构建其它天然产物的关键中间体, 其高效合成在有机化学和药物化学领域备受关注. 这类化合物因其独特的中环骨架且具有良好的生物活性, 在过去十年间其合成的方法得到了很大的发展, 也成为了当前中环化合物合成的研究热点之一. 本综述系统梳理了过去十年来十元氮杂环化合物合成的研究进展, 介绍了该类化合物的创新合成方法及其在十元氮杂环天然产物全合成领域的最新应用.

关键词: 十元氮杂环化合物, 中环化合物, 环化反应, 环加成反应, 扩环反应

Ten-membered nitrogen heterocyclic compounds, are not only the cores of many nitrogen-containing alkaloids but also the key intermediates for the construction of other natural products. Consequently, their efficient synthesis has garnered significant attention in the field of organic and medicinal chemistry. Over the past decade, since their special medium-sized rings and possessing good biological activities, the synthetic methodologies toward the preparation of ten-membered N-heterocyclic compounds have been greatly developed and have also become one of the hottest topics in the medium-sized ring synthetic fields. This review summarized the recent advances in the synthesis of ten-membered N-heterocyclic compounds in the last decade. It covered the innovative synthetic methodologies for these ten-membered nitrogen heterocyclic compounds and their applications in the total synthesis of natural products.

Key words: ten-membered N-heterocyclic compounds, medium-sized ring compounds, cyclization reaction, cycloaddition reaction, ring expansion reaction

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罗艳, 刘章伟, 胡朝蕾, 闭红艳, 莫冬亮. 十元氮杂环化合物合成最新研究进展[J]. 有机化学, doi: 10.6023/cjoc202508004.

Luo Yan, Liu Zhang-Wei, Hu Zhaolei, Bi Hong-Yan, Mo Dong-Liang. Recent Advances on the Synthesis of Ten-Membered Nitrogen Heterocyclic Compounds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202508004.

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