来自海洋异壁放线菌OUCMDZ-413的一种新β-咔啉及其类似物

doi:10.6023/cjoc202509027

研究论文

来自海洋异壁放线菌OUCMDZ-413的一种新β-咔啉及其类似物

高谕康^a,†, 梅显贵^a,c,†, 刘樾^a, 付鹏^a,b, 刘培培^a,*, 朱伟明^a,b,*

(^a中国海洋大学医药学院海洋药物教育部重点实验室山东青岛 266003)
(^b青岛海洋科技中心海洋药物与生物制品功能实验室山东青岛 266237)
(^c山东农业大学农学院作物生物学国家重点实验室山东泰安 271018)

收稿日期:2025-09-22 修回日期:2025-11-04
作者简介:†共同第一作者.
基金资助:
国家自然科学基金(Nos. 82473838, 30572246)及国家自然科学基金-山东联合基金(No. U1906213)资助项目.

Discovery of a new β-carboline and its analogues from Actinoalloteichus cyanogriseus OUCMDZ-413

Gao Yukang^a,†, Mei Xiangui^a,c,†, Liu Yue^a, Fu Peng^a,b, Liu Peipei^a,*, Zhu Weiming^a,b,*

(^aKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003)
(^bLaboratory for Marine Drugs and Bioproducts, Marine Science and Technology Center, Qingdao, Shandong 266237)
(^cState Key Laboratory of Crop Biology, Agronomy College, Shandong Agricultural University, Taian, Shandong 271018)

Received:2025-09-22 Revised:2025-11-04
Contact: *E-mail: weimingzhu@ouc.edu.cn, liupeipei@ouc.edu.cn
About author:†These authors contributed equally to this work.
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 82473838, 30572246) and the National Natural Science Foundation of China-Shandong Fund Joint Project (No. U1906213).

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摘要/Abstract

首次从海洋来源的异壁放线菌Actinoalloteichus cyanogriseus OUCMDZ-413的发酵产物中发现了一种新的1-乙酰基-3-羟甲基-β-咔啉 (1) 和一种关键中间体 (S)-cyanogramide B (2),该中间体参与了 cyanogramide (6) 的生物合成;同时还获得了三种已知的类似物 (3-5)。通过核磁共振波谱全解析、比旋光和电子圆二色谱分析,确定了它们的化学结构。(S)-cyanogramide B (2) 的分离以及 cyanogramide (6) 的再次分离强调了发酵优化是挖掘微生物代谢潜力的有效策略,从而为发现菌株A. cyanogriseus OUCMDZ-413的化学多样性提供了参考。

关键词: 海洋放线菌, 异壁放线菌OUCMDZ-413, β-咔啉, 结构鉴定, 化学多样性

A new 1-acetyl-3-hydroxymethyl-β-carboline (1) and a key intermediate (S)-cyanogramide B (2), involved in the biosynthesis of cyanogramide (6), were isolated for the first time from the marine derived Actinoalloteichus cyanogriseus OUCMDZ-413, along with three know analogues (3-5). Their structures were fully elucidated through comprehensive nuclear magnetic resonance (NMR), specific rotation, and electronic circular dichroism (ECD) techniques. The isolation of (S)-cyanogramide B (2), along with the re-isolation of cyanogramide (6), highlights that fermentation optimization is an effective strategy for exploring the metabolic potential of microorganisms. These findings provide valuable insights into the metabolite diversity of A. cyanogriseus OUCMDZ-413.

Key words: marine actinobacteria, Actinoalloteichus cyanogriseus OUCMDZ-413, β-carboline, structural elucidation, chemodiversity

引用此文

高谕康, 梅显贵, 刘樾, 付鹏, 刘培培, 朱伟明. 来自海洋异壁放线菌OUCMDZ-413的一种新β-咔啉及其类似物[J]. 有机化学, doi: 10.6023/cjoc202509027.

Gao Yukang, Mei Xiangui, Liu Yue, Fu Peng, Liu Peipei, Zhu Weiming. Discovery of a new β-carboline and its analogues from Actinoalloteichus cyanogriseus OUCMDZ-413[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202509027.

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