银催化环状醛亚胺与草酸单烷基酯的脱羧C-H烷基化反应研究

doi:10.6023/cjoc202510026

摘要/Abstract

本文通过C-O键断裂策略实现了银催化的单烷基草酸酯与环状醛亚胺的脱羧Csp²-H键烷基化反应。该反应在温和的条件下进行,以中等的至良好的收率（30-80%）得到目标产物,且底物适用范围广泛。此外,我们还对生物活性分子的后期修饰及催化策略的进一步应用进行了研究。机理研究表明该反应经历自由基机理。

关键词: 银催化, C-H烷基化, 环状醛亚胺, 草酸单烷基酯, C-O键断裂

Silver-catalyzed decarboxylative Csp²-H alkylation of cyclic aldimines with monoalkyl oxalates via C-O bond cleavage has been realized under mild reaction conditions. The corresponding products were generated in moderate to good yields (30-80%) with wide substrate scope. In addition, late-stage modification of bioactive molecules, and further application of the catalytic strategy were also performed. The mechanistic studies show that the reaction undergoes a radical pathway.

Key words: Silver catalysis, C-H Alkylation, Cyclic aldimines, Monoalkyl oxalates, C-O Bond cleavage

引用此文

王晶晶, 于子涵, 岳开华, 伊茂聪, 张安东, 丁同惠, 王翠洁, 崔明月, 廖科超, 李峰. 银催化环状醛亚胺与草酸单烷基酯的脱羧C-H烷基化反应研究[J]. 有机化学, doi: 10.6023/cjoc202510026.

Wang Jingjing, Yu Zihan, Yue Kaihua, Yi Maocong, Zhang Andong,ding Tonghui, Wang Cuijie,cui Mingyue, Liao Kechao, Li Feng. Silver-Catalyzed Decarboxylative C-H Alkylation of Cyclic Aldimines with Monoalkyl Oxalates[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202510026.

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