基于钴催化的碳-硫键构建研究进展

doi:10.6023/cjoc202603022

摘要/Abstract

有机硫化合物广泛的应用价值,使得碳-硫键的高效、高选择性构建成为合成化学领域的重要研究方向。近年来,基于丰产金属钴催化的碳-硫键构建反应取得了显著的研究进展。这一发展在很大程度上得益于钴元素储量丰富、价格低廉、价态多样以及生物毒性较低等优势,为温和条件下的高效硫化反应实现优异的化学选择性与官能团耐受性,乃至新颖反应机制的发掘,提供了重要支撑。本综述系统梳理了近五年来钴催化碳-硫键构建的最新成果,涵盖硫醚、砜、硫杂环化合物、亚砜、亚磺酰胺、二硫醚及硫醇等有机硫化合物的合成方法,重点总结其研究背景、底物适用范围及反应路径,并对该领域的未来发展趋势进行了展望。

关键词: 钴催化, 碳-硫键构建, 硫化反应, 有机硫化合物

The broad application value of organosulfur compounds has made the efficient and highly selective construction of carbon-sulfur (C-S) bonds a key research focus in synthetic chemistry. In recent years, significant progress has been made in cobalt-catalyzed C-S bond formation, leveraging the advantages of cobalt as an earth-abundant element. To a large extent, this progress is attributed to the inherent advantages of cobalt's natural abundance, low cost, variable oxidation states, and relatively low biotoxicity. These features enable efficient sulfurization reactions under mild conditions, achieve excellent chemo-selectivity and functional group tolerance, and even facilitate the discovery of novel reaction mechanisms. This review systematically summarizes the latest advances in cobalt-catalyzed C-S bond formation over the past five years, covering synthetic methods for various organosulfur compounds including thioethers, sulfones, sulfur-containing heterocycles, sulfoxides, sulfinamides, disulfides, and thiols. It highlights the research background, substrate scope, and reaction pathways, and offers perspectives on future developments in this field.

Key words: Cobalt catalysis, C-S bond formation, Sulfurization reaction, Organosulfurs

引用此文

肖潜, 钟建基. 基于钴催化的碳-硫键构建研究进展[J]. 有机化学, doi: 10.6023/cjoc202603022.

Xiao Qian, Zhong Jian-Ji. Recent Advances in Cobalt-Catalysis for C-S Bond Formation[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603022.

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