丰产金属钴催化的烯烃氢酰化反应

doi:10.6023/cjoc202601004

摘要/Abstract

过渡金属催化烯烃氢酰化反应可快捷、高效且原子经济性地合成酮类化合物. 近年来, 丰产金属钴催化剂因其廉价易得、生物毒性低以及多样化的催化性能及选择性, 受到有机化学研究者的广泛关注. 总结了过去五年来钴催化或光/钴协同催化烯烃氢酰化反应的研究进展, 依据酰基来源对氢酰化反应进行分类, 并系统阐述了催化类型、底物适用范围及反应机理.

关键词: 氢酰化反应, 烯烃, 钴催化, 酮, 选择性

Transition-metal-catalyzed hydroacylation of alkenes enables convenient, efficient, and atom-economical synthesis of ketone products. In recent years, earth-abundant cobalt catalysts have received considerable attention from organic chemists due to their cost-effectiveness, low biological toxicity, and versatile catalytic performance and selectivity. This review summarizes recent progress in alkene hydroacylation under single-component cobalt catalysis or photo/cobalt synergistic catalysis over the past five years, categorizes the hydroacylation reactions according to the type of acyl sources, and comprehensively elaborates the catalytic modes, substrate scope, and reaction mechanisms.

Key words: hydroacylation, alkenes, cobalt catalysis, ketones, selectivity

引用此文

任汝通, 卢诗超, 李洪爽. 丰产金属钴催化的烯烃氢酰化反应[J]. 有机化学, 2026, 46(7): 2701-2712.

Rutong Ren, Shichao Lu, Hongshuang Li. Earth-Abundant Cobalt-Catalyzed Alkene Hydroacylation[J]. Chinese Journal of Organic Chemistry, 2026, 46(7): 2701-2712.

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图/表 12

Figure 1. Strategies for alkene hydroacylation under cobalt catalysis

Scheme 1. Regioselective hydroacylation with aldehydes or other acyl sources

Scheme 2. Regioselective hydroacylation of 1,3-dienes with non-chelating aldehydes

Scheme 3. Enantioselective hydroacylation of 1,3-dienes with simple aldehydes

Scheme 4. Single-component and in situ-generated CoI-catalysts for 1,3-diene hydroacylation

Scheme 5. Anti-Markovnikov hydroacylation of aryl alkenes with simple aldehydes

Scheme 6. Quadruple catalysis for Markovnikov hydroacylation of (hetero)aryl alkenes

Scheme 7. Oxidative hydroacylation of alkenes with primary alcohols

Scheme 8. Radical hydroacylation of unactivated alkenes with acylphosphonates

Scheme 9. Triple catalysis for Markovnikov hydroacylation of aryl alkenes

Scheme 10. Synergistic hydroacylation of electron-deficient alkenes with anhydrides

Scheme 11. Radical hydroacylation of aryl alkenes with acyl triazoles

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