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有机化学
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有机化学 ›› 1987, Vol. 7 ›› Issue (4): 285-288. 上一篇    下一篇

研究论文

具有生物活性的有机硅化合物的研究VII.1-芳酰氧基-2,8,9-三氧杂-5-氮杂-1-硅杂三环[3,3,3,0[1.5]]十一碳烷的研究

王积涛;谢庆兰;廖仁安;李靖;林秀云   

  1. 南开大学元素有机化学研究所
  • 发布日期:1987-08-25

Studies on organosilicon compounds with biological activity VIII. Study of 1-arylacyloxy-2,8,9-trioxa-5-aza-1-silatricyclo [3.3.3.0[1.5]] undecanes

WANG JITAO;XIE QINGLAN;LIAO RENAN;LI JING;LIN XIUYUN   

  • Published:1987-08-25

用新的方法合成了九个1-芳酰氧基2,8,9-三氧杂-5-氮杂-1-硅杂三环[3.3.3.0[1,5]]十一碳烷(简称 1-芳酰氧基杂氮硅三环)。本方法具有产率高,后处理简便等优点。X-射线晶格衍射确定了该类化合物分子内N→Si键键长较短,说明配键强度较大。报道该类化合物的IR, 1H NMR及MS,并讨论了质谱断裂机理。

关键词: 质子磁共振谱法, 生物活性, 十一碳化合物, Ｘ射线衍射分析, 氮杂环化合物, 质谱法, 氧杂环化合物, 硅杂环化合物, 有机硅化合物, 三环烃 P

Nine 1-arylacyloxy-2,8,9-trioxa-5-aza-1-silatricyclo[3.3.3.01,5]undecanes were synthesized by reaction between 1-bromosilatrane and substituted benzoic acids. The crystal structure of I was studied by X-ray diffraction, confirming the 5-coordinated structures of these compounds The intramol. N甋i bond was stronger than that of ordinary silatranes. The 1H NMR and IR of these compounds were studied and the mass spectral fragmentation paths was rationalized.

Key words: X-RAY DIFFRACTION ANALYSIS, MASS SPECTROGRAPHY, NITROGEN HETEROCYCLICS, PROTON MAGNETIC RESONANCE SPECTROMETRY, C11 COMPOUNDS, SILICON HETEROCYCLICS COMPOUNDS, TRICYCLIC HYDROCARBON P, OXYGEN HETEROCYCLICS, ORGANO SILICON COMPOUNDS, BIOLOGICAL ACTIVITY

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