有机化学 ›› 1987, Vol. 7 ›› Issue (6): 449-451. 上一篇    下一篇

研究论文

丁基氟脲嘧啶的β-D葡萄吡喃糖苷的合成

孙昌俊   

  1. 山东大学化学系
  • 发布日期:1987-12-25

Synthesis of \b\-glucopyranosides of butyl fluorouracil

SUN CHANGJUN   

  • Published:1987-12-25

关键词: 氟脲嘧啶, 抗癌药, 三甲基烷基铵, 吡喃糖, 葡萄糖, 相转移催化, 糖苷, 苄胺翁 P

2-O-Butyl-3-(2',3',4',6'-tetra-O-acetyl-b-D-glucopyranosyl)-5-fluorouracil (I) and 2-O-butyl-4-O-(2',3',4',6'-tetra-O-acetyl-b-D-glucopyranosyl)-5-fluoroura cil (II) were synthesized from 2,3,4,6-tetra-O-acetyl-1-bromo-1-deoxy-a-D-glucopyranose (III) and 2-O-n-butyl-5-fluorouracil under phase transfer catalysis. II was also synthesized by reaction of III with 2-O-butyl-5-fluorouracil silver. I and II were treated with ammonia to obtain 2-O-butyl-3-(b-D-glucopyranosyl)-5-fluorouracil and 2-O-butyl-4-O-(b-D-glucopyranosyl)-5-fluorouracil resp.

Key words: FLUOROURACILUM, ANTICARCINOGEN, TRIMETHYLALKYLAMMONIUM, PYRANOSE, GLUCOSE, PHASE TRANSFER CATALYSIS, GLYCOSIDE, BENZENEMETHANAMINIUM P

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