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有机化学
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有机化学 ›› 1999, Vol. 19 ›› Issue (3): 316-320. 上一篇    下一篇

研究论文

2, 5-二取代基-1, 3, 4-恶二唑及恶二唑啉类化合物的合成

刘方明;于建新;王玮;刘罡;刘育亭;陈耀祖   

  1. 新疆大学化学系.新疆(830046);浙江大学化学系.杭州(310027)
  • 发布日期:1999-06-25

Synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazoles and oxadiazolines

Liu Fangming;Yu Jianxin;Wang Wei;Liu Gang;Liu Yuting;Chen Yaozu   

  1. Xinjiang Univ, Dept Chem.Xinjiang(830046);Zhejiang Univ, Dept Chem. Hangzhou(310027)
  • Published:1999-06-25

2-苯基-1,2,3-连三唑-4-甲酰肼(1)与芳酸在POCl~3催化下得到6种新的2-芳基-5-(2'-苯基-1',2',3'-连三唑-4'-基)-1,3,4-恶二唑(2)。1与羰基化合物缩合得到相应的酰腙(3),在Ac~2O作用下环化成2-取代基-3-乙酰基-5-(2'-苯基-1',2',3'-连三唑-4'-基)-1,3,4-恶二唑啉(4)。化合物的结构经元素分析,IR,^1HNMR和MS确证。

关键词: 酰腙, 芳酸, 合成, 元素分析, 恶二唑, 甲酰肼, 三唑, 恶唑啉, 唑类化合物

By the condensation of 2-phenyl-1, 2, 3-triazole-4-formyl hydrazide (1) with substituted benzoic acids in the presence of phosphorus oxychloride, six novel 2-aryl-5-(2'-phenyl-1', 2', 3'-triazole-4'-yl)- 1, 3, 4-oxadiazoles (2) were obtained. Reaction of acid hydrazide (1) with keto compounds gives corresponding hydrazones (3), which could be readily converted to their congener oxadiazolines (4) in good yields by treatment with Ac~2O. Their structures were established by elemental analysis, IR, ^1H NMR and MS spectroscopy.

Key words: FURODIAZOLE (=OXDIAZOLE), SYNTHESIS, ACYLHYDRAZONE, OXAZOLINE, FORMHYDRAZIDE (=FORMYL HYDRAZINE), TRIAZOLE, ELEMENTAL ANALYSIS

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