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有机化学
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有机化学 ›› 2000, Vol. 20 ›› Issue (1): 81-87. 上一篇    下一篇

研究论文

日本续断中新的双糖链三萜皂苷的结构研究

缪振春;周永新;冯锐;魏锋   

  1. 军事医学科学院毒物药物研究所.北京(100Act);北京江中药物研究报
  • 发布日期:2000-02-25

Structural determniation of A new bidesmosidic triterpenoid glycoside from dipsocus japonicus

Miao Zhenchun;Zhou Yongxin;Feng Rui;Wei Feng   

  1. Institute of Pharmacology and toxicology Academy of Military Med. Beijing(100Act)
  • Published:2000-02-25

PDF

832

被引次数

6

从日本续断根部的乙醇提取物中分得一个新的三萜皂苷。经过测定，它为：3-O-α-L-吡喃鼠李糖(1→3)-β-D-吡喃葡萄糖(1→3)-α-L-吡喃鼠李糖(1→2)-α-L-吡喃阿拉伯糖9常春藤苷元－28-O-β-吡喃葡萄糖酯苷)。结果表明，采用一维SEMDY，旋转坐标NOE差谱和选择性远程DEPT核磁共振新技术相结合的方法测定糖链结构不需要对化合物进行化学降解或衍生化，方法简便、快速，测定结果可靠，每个糖基的信号可以分辨和明确归属。

关键词: 日本续断, 三萜, 皂角苷, 吡喃P, 鼠李糖, 葡萄糖, 阿拉伯糖

A new 3,28 - bidensmosidic triterpenoid saponin was isolatde from the ethanolic extract of the root of Dipsocus japonicus and its structure established as 3-O-α-L- rhammopyranosyl (1→3) -β- D - glycopranosyl (1→3) -α- L - rhammopyranosyl(1→2) -α-L- arabinopyranosyl - hederagenin -28 -O -β- D -glycopranoside. The results obrained showed that the chemical structure of oligosaccharide chains of the saponin could be elucidated by the combination of 1D - SEMDY, NOE difference spectroscopy in rotating frame and selective long - range DEPT techniques, without having recourse to chemical degration or modification. Complete assignments of severely overlapping proton resonance of the sugar residues were obtained.

Key words: DIPSACUS ASPER, TRITERPENE, SAPONINS, PYRANE P, RHAMNOSE, GLUCOSE, ARABINOSE

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