有机化学 ›› 2000, Vol. 20 ›› Issue (4): 522-528. 上一篇    下一篇

研究论文

多乙酰氧基烷基卓酮的合成

尹炳柱;森章;竹下齐   

  1. 延边大学化学系;九州大学机能物质研究所
  • 发布日期:2000-08-25

Synthesis of polyacetoxyalkyltropones and polyhydroxyalkyltropones

Yin Bingzhu;Sen Zhang;Zhu Xiaqi   

  • Published:2000-08-25

各种溴代的烷基卓酚酮的乙酸酯用乙酸酐/三氟乙酸酐/乙酸(以下简称ATA)醋解可得高收率的相应的多乙酰氧基烷基卓酮,后者经稀酸水解几乎定量地得多羟基烷基卓酮。部分多乙酰氧基卓酮对肺癌A~5~4~9和上皮细胞癌显出抑制活性。

关键词: 卓酮, 乙酰氧基, 醋解, 乙酸酐, 乙酸, 三氟乙酸酐, 生理生化特性

In this paper, a series of polyacetoxyalkyltropones and polyhydroxyalkyltroponeswere synthesized by the reaction of polybromo- substituted alkyltropolones with acetyl trifuluoroacetate. The results of preliminary pharmacological test indicated that some poly- acetoxyalkyltropones had the inhibition effect against cells of KB and A549 in vitro.

Key words: ACETOXY GROUP, ACETOLYSIS, ACETIC ANHYDRIDE, ACETIC ACID, PHYSICOCHEMICAL CHARACTERISTICS

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