关键词: 环氧水解酶, 手征性, 手性二醇, 立体选择性, 水解酶, 不对称反应, 环氧化物

This article summarizes the development of the epoxide hydrolases in asymmetric synthesis. Epoxide hydrolases are prevalent in the nature, especially in the microbial sources. EHs appear high enantio- and regioselective in hydrolyzing epoxides to give the corresponding vicinal diols. Recently, some groups used the biochemical catalysis and chemical catalysis in a one-pot manner to hydrolyze the epoxides into single diols with satisfaction yields and high enantiomeric excess. This progress paved the way for using the EHs in the fine organic industry.

Key words: CHIRALITY, STEREOSELECTIVITY, HYDROLASE, EPOXIDE