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有机化学
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有机化学 ›› 2000, Vol. 20 ›› Issue (5): 815-819. 上一篇    下一篇

研究论文

三氯化铁催化的一锅法合成3,4-二氢嘧啶-2-酮

路军;马怀让;李万华   

  1. 西北大学化学系.西安(710069);西北大学化学工程系.西安(710069)
  • 发布日期:2000-10-25

A novel one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones by catalyzed ferric chloride hexahydrate

Lu Jun;Ma Huairang;Li Wanhua   

  1. Northwest Univ, Dept Chem.Xian(710069);Northwest Univ, Dept Chem Eng. Xian(710069)
  • Published:2000-10-25

PDF

732

被引次数

193

六水合三氯化铁催化下，β-酮酸酯、芳香醛、脲(1:1:1.5)在无水乙醇中进行环化缩合反应，合成了3,4-二氢嘧啶-2-酮衍生物，改进了Biginelli用盐酸为催化剂的一锅法反应，缩短了反应时间，操作简便，产率高达80%～90%，且Fe^3^+对环境友好。

关键词: 氯化铁, 环化, 缩合反应, 催化剂, 一锅法, 二氢嘧啶P, 嘧啶酮P

The syntheses of dihydropyrimidinones by a one-pot cyclocondensation of aldehydes, β-keto ester, and ureas (1:1:1.5) using ferric chloride hexahydrate as catalyst and alcohol as solvent are presented. The modified one-pot Biginelli's cyclocondensation not only features short reaction period, simple operation and high yield (80%～90%), but also is environment friendly.

Key words: IRON CHLORIDE, CYCLIZATION, CONDENSATION REACTION, CATALYST, PYRIMIDONE P

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